Brand name: methotrexate
Generic name: Rheumatrex, amethopterin, Methoblastin, Emthexate, MTX

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However, elderly patients are more likely to have age-related renal function impairment, which may require adjustment of dosage in patients receiving leucovorin as a rescue from the effects of high-dose methotrexate. Antibodies developed in 12% of patients on adalimumab monotherapy and in 1% of patients on concurrent methotrexate. His only other medications were amlodipine (5 mg per day) and methotrexate (15 mg per week). Leucovorin given at the appropriate time rescues bone marrow and gastrointestinal cells from methotrexate but has no apparent effect on pre-existing methotrexate nephrotoxicity. Such patients require especially careful monitoring for toxicity, and require dose reduction or, in some cases, discontinuation of methotrexate administration. No interference occurs, however, if methotrexate is measured by a radioimmunoassay (RIA). Pregnant women with psoriasis or rheumatoid arthritis should not receive methotrexate (See CONTRAINDICATIONS). MANAGEMENT: The use of methotrexate in combination with other potentially hepatotoxic agents (e.

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